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Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.

Publication ,  Journal Article
Beebe-Dimmer, JL; Lange, LA; Cain, JE; Lewis, RC; Ray, AM; Sarma, AV; Lange, EM; Cooney, KA
Published in: Prostate Cancer Prostatic Dis
2006

A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms (SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this finding, DNA samples from 475 African-American men were genotyped for the same SNPs and no association was observed with either serum PSA level or prostate cancer diagnosis.

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Published In

Prostate Cancer Prostatic Dis

DOI

ISSN

1365-7852

Publication Date

2006

Volume

9

Issue

1

Start / End Page

50 / 55

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Genotype
 

Citation

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Beebe-Dimmer, J. L., Lange, L. A., Cain, J. E., Lewis, R. C., Ray, A. M., Sarma, A. V., … Cooney, K. A. (2006). Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men. Prostate Cancer Prostatic Dis, 9(1), 50–55. https://doi.org/10.1038/sj.pcan.4500840
Beebe-Dimmer, J. L., L. A. Lange, J. E. Cain, R. C. Lewis, A. M. Ray, A. V. Sarma, E. M. Lange, and K. A. Cooney. “Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.Prostate Cancer Prostatic Dis 9, no. 1 (2006): 50–55. https://doi.org/10.1038/sj.pcan.4500840.
Beebe-Dimmer JL, Lange LA, Cain JE, Lewis RC, Ray AM, Sarma AV, et al. Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men. Prostate Cancer Prostatic Dis. 2006;9(1):50–5.
Beebe-Dimmer, J. L., et al. “Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.Prostate Cancer Prostatic Dis, vol. 9, no. 1, 2006, pp. 50–55. Pubmed, doi:10.1038/sj.pcan.4500840.
Beebe-Dimmer JL, Lange LA, Cain JE, Lewis RC, Ray AM, Sarma AV, Lange EM, Cooney KA. Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men. Prostate Cancer Prostatic Dis. 2006;9(1):50–55.

Published In

Prostate Cancer Prostatic Dis

DOI

ISSN

1365-7852

Publication Date

2006

Volume

9

Issue

1

Start / End Page

50 / 55

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Promoter Regions, Genetic
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Humans
  • Genotype