Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.


Journal Article

A major problem with the use of serum prostate-specific antigen (PSA) in predicting prostate cancer risk is the considerable variability of such measurements. Cramer et al. identified a set of single-nucleotide polymorphisms (SNPs) in the upstream regulatory region of the PSA gene that were each associated with increased promoter activity and serum PSA, further suggesting that genotyping these SNPs could be useful in improving the predictive value of PSA screening. In order to replicate this finding, DNA samples from 475 African-American men were genotyped for the same SNPs and no association was observed with either serum PSA level or prostate cancer diagnosis.

Full Text

Duke Authors

Cited Authors

  • Beebe-Dimmer, JL; Lange, LA; Cain, JE; Lewis, RC; Ray, AM; Sarma, AV; Lange, EM; Cooney, KA

Published Date

  • 2006

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 50 - 55

PubMed ID

  • 16247489

Pubmed Central ID

  • 16247489

International Standard Serial Number (ISSN)

  • 1365-7852

Digital Object Identifier (DOI)

  • 10.1038/sj.pcan.4500840


  • eng

Conference Location

  • England