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Validation of genome-wide prostate cancer associations in men of African descent.

Publication ,  Journal Article
Chang, B-L; Spangler, E; Gallagher, S; Haiman, CA; Henderson, B; Isaacs, W; Benford, ML; Kidd, LR; Cooney, K; Strom, S; Ingles, SA; Stern, MC ...
Published in: Cancer Epidemiol Biomarkers Prev
January 2011

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. METHODS: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci. RESULTS: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. CONCLUSION: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations. IMPACT: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 2011

Volume

20

Issue

1

Start / End Page

23 / 32

Location

United States

Related Subject Headings

  • United States
  • United Kingdom
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chang, B.-L., Spangler, E., Gallagher, S., Haiman, C. A., Henderson, B., Isaacs, W., … Rebbeck, T. R. (2011). Validation of genome-wide prostate cancer associations in men of African descent. Cancer Epidemiol Biomarkers Prev, 20(1), 23–32. https://doi.org/10.1158/1055-9965.EPI-10-0698
Chang, Bao-Li, Elaine Spangler, Stephen Gallagher, Christopher A. Haiman, Brian Henderson, William Isaacs, Marnita L. Benford, et al. “Validation of genome-wide prostate cancer associations in men of African descent.Cancer Epidemiol Biomarkers Prev 20, no. 1 (January 2011): 23–32. https://doi.org/10.1158/1055-9965.EPI-10-0698.
Chang B-L, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, et al. Validation of genome-wide prostate cancer associations in men of African descent. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23–32.
Chang, Bao-Li, et al. “Validation of genome-wide prostate cancer associations in men of African descent.Cancer Epidemiol Biomarkers Prev, vol. 20, no. 1, Jan. 2011, pp. 23–32. Pubmed, doi:10.1158/1055-9965.EPI-10-0698.
Chang B-L, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel AS, Thompson IM, Leach RJ, Ostrander EA, Stanford JL, Witte J, Casey G, Eeles R, Hsing AW, Chanock S, Hu JJ, John EM, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck TR. Validation of genome-wide prostate cancer associations in men of African descent. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23–32.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 2011

Volume

20

Issue

1

Start / End Page

23 / 32

Location

United States

Related Subject Headings

  • United States
  • United Kingdom
  • Reproducibility of Results
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human