Decreasing age at prostate cancer diagnosis over successive generations in prostate cancer families.


Journal Article

BACKGROUND: The decline in age at prostate cancer diagnosis over the past decade is partially attributable to prostate specific antigen (PSA) screening. We examined age at diagnosis over successive generations within prostate cancer families. METHODS: Families with at least two affected men were selected from the University of Michigan Prostate Cancer Genetics Project. The 1,345 individuals from 489 families were grouped into three generations. RESULTS: Risk of prostate cancer diagnosis at a given age was estimated to increase 1.31 (95% CI: 1.13-1.51) times from one generation to the next. Among men diagnosed prior to the PSA era, inferences were similar (hazard ratio = 1.28, 95% CI: 0.97-1.68). No maternal versus paternal disease transmission effect was observed. CONCLUSIONS: Age at prostate cancer diagnosis was observed to decrease over successive generations in families from an ongoing familial prostate cancer study. This finding, if confirmed, may have important implications for familial prostate cancer risk assessment.

Full Text

Duke Authors

Cited Authors

  • Bock, CH; Peyser, PA; Montie, JE; Cooney, KA

Published Date

  • June 2005

Published In

Volume / Issue

  • 64 / 1

Start / End Page

  • 60 - 66

PubMed ID

  • 15651090

Pubmed Central ID

  • 15651090

Electronic International Standard Serial Number (EISSN)

  • 1097-0045

International Standard Serial Number (ISSN)

  • 0270-4137

Digital Object Identifier (DOI)

  • 10.1002/pros.20220


  • eng