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Hereditary prostate cancer in African-American families.

Publication ,  Journal Article
Cooney, KA
Published in: Semin Urol Oncol
November 1998

The recognition that family history is an important risk factor for the development of prostate cancer has led to the search for prostate cancer susceptibility genes. Although most prostate cancer linkage studies have focused on Caucasian families, there is epidemiological evidence indicating that the relative risk attributable to a positive family history is similar in African-American and Caucasian-American families. There are data to support the existence of two potential prostate cancer susceptibility genes both on the long arm of chromosome 1; these have been called HPC1 and HPC2. Studies from us and others have shown that HPC1 may contribute to the clustering of prostate cancer in some African-American families. African-American families with multiple cases of prostate cancer should be encouraged to participate in genetic research studies with the goal of identifying the molecular basis for inherited prostate cancer susceptibility in this population.

Duke Scholars

Published In

Semin Urol Oncol

ISSN

1081-0943

Publication Date

November 1998

Volume

16

Issue

4

Start / End Page

202 / 206

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Male
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Disease Susceptibility
  • Chromosomes, Human, Pair 1
  • Black People
  • 3211 Oncology and carcinogenesis
 

Citation

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ICMJE
MLA
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Cooney, K. A. (1998). Hereditary prostate cancer in African-American families. Semin Urol Oncol, 16(4), 202–206.
Cooney, K. A. “Hereditary prostate cancer in African-American families.Semin Urol Oncol 16, no. 4 (November 1998): 202–6.
Cooney KA. Hereditary prostate cancer in African-American families. Semin Urol Oncol. 1998 Nov;16(4):202–6.
Cooney, K. A. “Hereditary prostate cancer in African-American families.Semin Urol Oncol, vol. 16, no. 4, Nov. 1998, pp. 202–06.
Cooney KA. Hereditary prostate cancer in African-American families. Semin Urol Oncol. 1998 Nov;16(4):202–206.

Published In

Semin Urol Oncol

ISSN

1081-0943

Publication Date

November 1998

Volume

16

Issue

4

Start / End Page

202 / 206

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Male
  • Humans
  • Genes, Tumor Suppressor
  • Female
  • Disease Susceptibility
  • Chromosomes, Human, Pair 1
  • Black People
  • 3211 Oncology and carcinogenesis