Multiple regions within 8q24 independently affect risk for prostate cancer.

Journal Article (Journal Article)

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.

Full Text

Duke Authors

Cited Authors

  • Haiman, CA; Patterson, N; Freedman, ML; Myers, SR; Pike, MC; Waliszewska, A; Neubauer, J; Tandon, A; Schirmer, C; McDonald, GJ; Greenway, SC; Stram, DO; Le Marchand, L; Kolonel, LN; Frasco, M; Wong, D; Pooler, LC; Ardlie, K; Oakley-Girvan, I; Whittemore, AS; Cooney, KA; John, EM; Ingles, SA; Altshuler, D; Henderson, BE; Reich, D

Published Date

  • May 2007

Published In

Volume / Issue

  • 39 / 5

Start / End Page

  • 638 - 644

PubMed ID

  • 17401364

Pubmed Central ID

  • PMC2638766

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng2015


  • eng

Conference Location

  • United States