Collapsing glomerulopathy.

Published

Journal Article (Review)

Collapsing glomerulopathy (CG) has become an important cause of ESRD. First delineated from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common, distinct pattern of proliferative parenchymal injury that portends a rapid loss of renal function and poor responses to empiric therapy. Notwithstanding, the rise in disorders that are associated with CG, the identification of the first susceptibility genes for CG, the remarkable increase in murine modeling of CG, and promising preclinical testing of new therapeutic strategies suggest that the outlook for CG as a poorly understood and therapeutically resistant renal disease is set to change in the future. This focused review highlights recent advances in research into the pathogenesis and treatment of CG.

Full Text

Duke Authors

Cited Authors

  • Albaqumi, M; Soos, TJ; Barisoni, L; Nelson, PJ

Published Date

  • October 2006

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • 2854 - 2863

PubMed ID

  • 16914539

Pubmed Central ID

  • 16914539

International Standard Serial Number (ISSN)

  • 1046-6673

Digital Object Identifier (DOI)

  • 10.1681/ASN.2006030225

Language

  • eng

Conference Location

  • United States