Current views on collapsing glomerulopathy.

Published

Journal Article (Review)

Collapsing glomerulopathy is a proliferative disease defined by segmental or global wrinkling of the glomerular basement membranes associated with podocyte proliferation. These lesions are particularly poor responders to standard therapies. First described as an idiopathic disorder or following HIV infection, it is now associated with a broad group of diseases and different pathogenetic mechanisms, which participate in podocyte injury and mitogenic stimulation. Because of this etiologic heterogeneity, there is clear need for new therapeutic approaches to target each variant of this entity. Historical background, terminology, morphologic and phenotypic features, and suggested mechanisms are reviewed in this manuscript.

Full Text

Duke Authors

Cited Authors

  • Albaqumi, M; Barisoni, L

Published Date

  • July 2008

Published In

Volume / Issue

  • 19 / 7

Start / End Page

  • 1276 - 1281

PubMed ID

  • 18287560

Pubmed Central ID

  • 18287560

Electronic International Standard Serial Number (EISSN)

  • 1533-3450

Digital Object Identifier (DOI)

  • 10.1681/ASN.2007080926

Language

  • eng

Conference Location

  • United States