Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy.

Published

Journal Article

CONTEXT: Etiologic factors and pathways leading to altered podocyte phenotype are clearly numerous and involve the activity of different cellular function. OBJECTIVE: To focus on recent discoveries in podocyte biology and genetics and their relevance to these human glomerular diseases, named podocytopathies. DATA SOURCES: Genetic mutations in genes encoding for proteins in the nucleus, slit diaphragm, podocyte cytoplasm, and cell membrane are responsible for podocyte phenotype and functional abnormalities. Podocyte injury may also derive from secondary stimuli, such as mechanical stress, infections, or use of certain medications. Podocytes can respond to injury in a limited number of ways, which include (1) effacement, (2) apoptosis, (3) arrest of development, and (4) dedifferentiation. Each of these pathways results in a specific glomerular morphology: minimal change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy. CONCLUSIONS: Based on current knowledge of podocyte biology, we organized etiologic factors and morphologic features in a taxonomy of podocytopathies, which provides a novel approach to the classification of these diseases. Current and experimental therapeutic approaches are also discussed.

Full Text

Duke Authors

Cited Authors

  • Barisoni, L; Schnaper, HW; Kopp, JB

Published Date

  • February 2009

Published In

Volume / Issue

  • 133 / 2

Start / End Page

  • 201 - 216

PubMed ID

  • 19195964

Pubmed Central ID

  • 19195964

Electronic International Standard Serial Number (EISSN)

  • 1543-2165

Digital Object Identifier (DOI)

  • 10.1043/1543-2165-133.2.201

Language

  • eng

Conference Location

  • United States