Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.

Journal Article (Journal Article)

Cognitive impairment is a feature of many psychiatric diseases, including schizophrenia. Here we aim to identify multimodal biomarkers for quantifying and predicting cognitive performance in individuals with schizophrenia and healthy controls. A supervised learning strategy is used to guide three-way multimodal magnetic resonance imaging (MRI) fusion in two independent cohorts including both healthy individuals and individuals with schizophrenia using multiple cognitive domain scores. Results highlight the salience network (gray matter, GM), corpus callosum (fractional anisotropy, FA), central executive and default-mode networks (fractional amplitude of low-frequency fluctuation, fALFF) as modality-specific biomarkers of generalized cognition. FALFF features are found to be more sensitive to cognitive domain differences, while the salience network in GM and corpus callosum in FA are highly consistent and predictive of multiple cognitive domains. These modality-specific brain regions define-in three separate cohorts-promising co-varying multimodal signatures that can be used as predictors of multi-domain cognition.

Full Text

Duke Authors

Cited Authors

  • Sui, J; Qi, S; van Erp, TGM; Bustillo, J; Jiang, R; Lin, D; Turner, JA; Damaraju, E; Mayer, AR; Cui, Y; Fu, Z; Du, Y; Chen, J; Potkin, SG; Preda, A; Mathalon, DH; Ford, JM; Voyvodic, J; Mueller, BA; Belger, A; McEwen, SC; O'Leary, DS; McMahon, A; Jiang, T; Calhoun, VD

Published Date

  • August 2, 2018

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 3028 -

PubMed ID

  • 30072715

Pubmed Central ID

  • PMC6072778

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-018-05432-w


  • eng

Conference Location

  • England