An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Published

Journal Article

Pathogens have been a strong driving force for natural selection. Therefore, understanding how human genetic differences impact infection-related cellular traits can mechanistically link genetic variation to disease susceptibility. Here we report the Hi-HOST Phenome Project (H2P2): a catalog of cellular genome-wide association studies (GWAS) comprising 79 infection-related phenotypes in response to 8 pathogens in 528 lymphoblastoid cell lines. Seventeen loci surpass genome-wide significance for infection-associated phenotypes ranging from pathogen replication to cytokine production. We combined H2P2 with clinical association data from patients to identify a SNP near CXCL10 as a risk factor for inflammatory bowel disease. A SNP in the transcriptional repressor ZBTB20 demonstrated pleiotropy, likely through suppression of multiple target genes, and was associated with viral hepatitis. These data are available on a web portal to facilitate interpreting human genome variation through the lens of cell biology and should serve as a rich resource for the research community.

Full Text

Duke Authors

Cited Authors

  • Wang, L; Pittman, KJ; Barker, JR; Salinas, RE; Stanaway, IB; Williams, GD; Carroll, RJ; Balmat, T; Ingham, A; Gopalakrishnan, AM; Gibbs, KD; Antonia, AL; eMERGE Network, ; Heitman, J; Lee, SC; Jarvik, GP; Denny, JC; Horner, SM; DeLong, MR; Valdivia, RH; Crosslin, DR; Ko, DC

Published Date

  • August 2018

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 308 - 323.e6

PubMed ID

  • 30092202

Pubmed Central ID

  • 30092202

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

International Standard Serial Number (ISSN)

  • 1931-3128

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2018.07.007

Language

  • eng