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The host response as a tool for infectious disease diagnosis and management.

Publication ,  Journal Article
Lydon, EC; Ko, ER; Tsalik, EL
Published in: Expert Rev Mol Diagn
August 2018

A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks, and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, and over the past decade, there has been a particular focus on the host response. Since this article was originally published in 2015, there have been significant developments in the field of host response diagnostics, warranting this updated review. Areas Covered: This review begins by discussing developments in single biomarkers and pauci-analyte biomarker panels. It then delves into 'omics, an area where there has been truly exciting progress. Specifically, progress has been made in sepsis diagnosis and prognosis; differentiating viral, bacterial, and fungal pathogen classes; pre-symptomatic diagnosis; and understanding disease-specific diagnostic challenges in tuberculosis, Lyme disease, and Ebola. Expert Commentary: As 'omics have become faster, more precise, and less expensive, the door has been opened for academic, industry, and government efforts to develop host-based infectious disease classifiers. While there are still obstacles to overcome, the chasm separating these scientific advances from the patient's bedside is shrinking.

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Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

August 2018

Volume

18

Issue

8

Start / End Page

723 / 738

Location

England

Related Subject Headings

  • Molecular Diagnostic Techniques
  • Humans
  • Genomics
  • Communicable Diseases
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Lydon, E. C., Ko, E. R., & Tsalik, E. L. (2018). The host response as a tool for infectious disease diagnosis and management. Expert Rev Mol Diagn, 18(8), 723–738. https://doi.org/10.1080/14737159.2018.1493378
Lydon, Emily C., Emily R. Ko, and Ephraim L. Tsalik. “The host response as a tool for infectious disease diagnosis and management.Expert Rev Mol Diagn 18, no. 8 (August 2018): 723–38. https://doi.org/10.1080/14737159.2018.1493378.
Lydon EC, Ko ER, Tsalik EL. The host response as a tool for infectious disease diagnosis and management. Expert Rev Mol Diagn. 2018 Aug;18(8):723–38.
Lydon, Emily C., et al. “The host response as a tool for infectious disease diagnosis and management.Expert Rev Mol Diagn, vol. 18, no. 8, Aug. 2018, pp. 723–38. Pubmed, doi:10.1080/14737159.2018.1493378.
Lydon EC, Ko ER, Tsalik EL. The host response as a tool for infectious disease diagnosis and management. Expert Rev Mol Diagn. 2018 Aug;18(8):723–738.
Journal cover image

Published In

Expert Rev Mol Diagn

DOI

EISSN

1744-8352

Publication Date

August 2018

Volume

18

Issue

8

Start / End Page

723 / 738

Location

England

Related Subject Headings

  • Molecular Diagnostic Techniques
  • Humans
  • Genomics
  • Communicable Diseases
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences