Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.
Journal Article (Clinical Trial;Journal Article)
Emerging evidence supports the importance of ghrelin to defend against starvation-induced hypoglycemia. This effect may be mediated by inhibition of glucose-stimulated insulin secretion as well as reduced insulin sensitivity. However, administration of ghrelin during meal consumption also stimulates the release of glucagon-like peptide 1 (GLP-1), an incretin important in nutrient disposition. The objective of this study was to evaluate the interaction between ghrelin and GLP-1 on parameters of glucose tolerance following a mixed-nutrient meal. Fifteen healthy men and women completed the study. Each consumed a standard meal on four separate occasions with a superimposed infusion of 1) saline, 2) ghrelin, 3) the GLP-1 receptor antagonist exendin(9-39) (Ex9), or 4) combined ghrelin and Ex9. Similar to previous studies, infusion of ghrelin caused glucose intolerance, whereas Ex9 had a minimal effect. However, combined ghrelin and Ex9 resulted in greater postprandial glycemia than either alone, and this effect was associated with impaired β-cell function and decreased glucose clearance. These findings suggest that in the fed state, stimulation of GLP-1 mitigates some of the effect of ghrelin on glucose tolerance. This novel interaction between gastrointestinal hormones suggests a system that balances insulin secretion and glucose disposal in the fed and fasting states.
Full Text
Duke Authors
Cited Authors
- Page, LC; Gastaldelli, A; Gray, SM; D'Alessio, DA; Tong, J
Published Date
- October 2018
Published In
Volume / Issue
- 67 / 10
Start / End Page
- 1976 - 1985
PubMed ID
- 30065032
Pubmed Central ID
- PMC6152343
Electronic International Standard Serial Number (EISSN)
- 1939-327X
Digital Object Identifier (DOI)
- 10.2337/db18-0451
Language
- eng
Conference Location
- United States