GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice.

Journal Article (Journal Article)

Heatstroke is still a potentially fatal threat during summer heat waves, despite improved prevention and treatment. It is reported that the transient receptor potential vanilloid 4 (TRPV4) inhibitor may protect septicemia mice. Many aspects of heatstroke have been defined, from the sepsis-mimic inflammatory response to hyperthermia. Hence, TRPV4 may be a therapeutic target for heatstroke. The results in murine models of heatstroke verified that GSK2193874, as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature, the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P<0.05). But GSK2193874 treatment before heat stress did not improve the symptoms of heatstroke mice. Therefore, TRPV4 should be involved in heatstroke-induced injury. Timely GSK2193874 administration may be useful to reduce heatstroke-induced injury. TRPV4 may be a potential new therapeutic target in fatal heatstroke.

Duke Authors

Cited Authors

  • Zhu, Y-H; Pei, Z-M

Published Date

  • May 2018

Published In

Volume / Issue

  • 64 / 7

Start / End Page

  • 36 - 42

PubMed ID

  • 29974844

Electronic International Standard Serial Number (EISSN)

  • 1165-158X

International Standard Serial Number (ISSN)

  • 0145-5680


  • eng