G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
Published
Journal Article (Review)
Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors.
Full Text
Duke Authors
Cited Authors
- Tsvetanova, NG; Irannejad, R; von Zastrow, M
Published Date
- March 13, 2015
Published In
Volume / Issue
- 290 / 11
Start / End Page
- 6689 - 6696
PubMed ID
- 25605726
Pubmed Central ID
- 25605726
Electronic International Standard Serial Number (EISSN)
- 1083-351X
Digital Object Identifier (DOI)
- 10.1074/jbc.R114.617951
Language
- eng
Conference Location
- United States