G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.

Journal Article (Journal Article;Review)

Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors.

Full Text

Duke Authors

Cited Authors

  • Tsvetanova, NG; Irannejad, R; von Zastrow, M

Published Date

  • March 13, 2015

Published In

Volume / Issue

  • 290 / 11

Start / End Page

  • 6689 - 6696

PubMed ID

  • 25605726

Pubmed Central ID

  • PMC4358092

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

Digital Object Identifier (DOI)

  • 10.1074/jbc.R114.617951


  • eng

Conference Location

  • United States