G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.
Publication
, Journal Article
Tsvetanova, NG; Irannejad, R; von Zastrow, M
Published in: J Biol Chem
March 13, 2015
Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization. We briefly summarize evidence supporting this view and then discuss what is presently known about the functional significance of GPCR-G protein activation in endosomes. Endosomal activation can shape the cellular response temporally by prolonging its overall duration, and may shape the response spatially by moving the location of intracellular second messenger production relative to effectors.
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Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
March 13, 2015
Volume
290
Issue
11
Start / End Page
6689 / 6696
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Humans
- Heterotrimeric GTP-Binding Proteins
- Endosomes
- Endocytosis
- Cyclic AMP
- Biosensing Techniques
- Biochemistry & Molecular Biology
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Tsvetanova, N. G., Irannejad, R., & von Zastrow, M. (2015). G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem, 290(11), 6689–6696. https://doi.org/10.1074/jbc.R114.617951
Tsvetanova, Nikoleta G., Roshanak Irannejad, and Mark von Zastrow. “G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.” J Biol Chem 290, no. 11 (March 13, 2015): 6689–96. https://doi.org/10.1074/jbc.R114.617951.
Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13;290(11):6689–96.
Tsvetanova, Nikoleta G., et al. “G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.” J Biol Chem, vol. 290, no. 11, Mar. 2015, pp. 6689–96. Pubmed, doi:10.1074/jbc.R114.617951.
Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13;290(11):6689–6696.
Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
March 13, 2015
Volume
290
Issue
11
Start / End Page
6689 / 6696
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Humans
- Heterotrimeric GTP-Binding Proteins
- Endosomes
- Endocytosis
- Cyclic AMP
- Biosensing Techniques
- Biochemistry & Molecular Biology
- Animals