The secretory pathway in control of endoplasmic reticulum homeostasis.

Published

Journal Article

In eukaryotic cells, proteins and membranes are transported between successive compartments by vesicle trafficking. Since precise protein localization is crucial for a range of cellular functions, it is not surprising that vesicle trafficking plays a role in many processes, including cell division, signaling, development, and even gene expression. We recently found evidence that the yeast secretory pathway directly regulates the dynamics of a key cell survival process, the unfolded protein response (UPR). UPR activation requires the processing of the transcription factor encoding RNA HAC1. We showed that the small yeast GTPase Ypt1, which regulates endoplasmic reticulum-to-Golgi trafficking, associates with and controls the RNA stability of unspliced HAC1 under normal growth conditions. Other small GTPases of the Ypt family also interacted with the unprocessed RNA. Here we speculate about the possible mechanism behind this novel secretory pathway-dependent regulation of endoplasmic reticulum homeostasis.

Full Text

Duke Authors

Cited Authors

  • Tsvetanova, NG

Published Date

  • January 2013

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 28 - 33

PubMed ID

  • 23235440

Pubmed Central ID

  • 23235440

Electronic International Standard Serial Number (EISSN)

  • 2154-1256

Digital Object Identifier (DOI)

  • 10.4161/sgtp.22599

Language

  • eng

Conference Location

  • United States