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Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.

Publication ,  Journal Article
Guo, J; Otis, JM; Higginbotham, H; Monckton, C; Cheng, J; Asokan, A; Mykytyn, K; Caspary, T; Stuber, GD; Anton, ES
Published in: Dev Cell
August 7, 2017

Appropriate growth and synaptic integration of GABAergic inhibitory interneurons are essential for functional neural circuits in the brain. Here, we demonstrate that disruption of primary cilia function following the selective loss of ciliary GTPase Arl13b in interneurons impairs interneuronal morphology and synaptic connectivity, leading to altered excitatory/inhibitory activity balance. The altered morphology and connectivity of cilia mutant interneurons and the functional deficits are rescued by either chemogenetic activation of ciliary G-protein-coupled receptor (GPCR) signaling or the selective induction of Sstr3, a ciliary GPCR, in Arl13b-deficient cilia. Our results thus define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal connectivity and inhibitory circuit formation.

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Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

August 7, 2017

Volume

42

Issue

3

Start / End Page

286 / 300.e4

Location

United States

Related Subject Headings

  • Synaptic Potentials
  • Synapses
  • Signal Transduction
  • Receptors, Somatostatin
  • Neurogenesis
  • Mice
  • Interneurons
  • Developmental Biology
  • Cilia
  • Cells, Cultured
 

Citation

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Chicago
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Guo, J., Otis, J. M., Higginbotham, H., Monckton, C., Cheng, J., Asokan, A., … Anton, E. S. (2017). Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. Dev Cell, 42(3), 286-300.e4. https://doi.org/10.1016/j.devcel.2017.07.010
Guo, Jiami, James M. Otis, Holden Higginbotham, Chase Monckton, JrGang Cheng, Aravind Asokan, Kirk Mykytyn, Tamara Caspary, Garret D. Stuber, and E. S. Anton. “Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.Dev Cell 42, no. 3 (August 7, 2017): 286-300.e4. https://doi.org/10.1016/j.devcel.2017.07.010.
Guo J, Otis JM, Higginbotham H, Monckton C, Cheng J, Asokan A, et al. Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. Dev Cell. 2017 Aug 7;42(3):286-300.e4.
Guo, Jiami, et al. “Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.Dev Cell, vol. 42, no. 3, Aug. 2017, pp. 286-300.e4. Pubmed, doi:10.1016/j.devcel.2017.07.010.
Guo J, Otis JM, Higginbotham H, Monckton C, Cheng J, Asokan A, Mykytyn K, Caspary T, Stuber GD, Anton ES. Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. Dev Cell. 2017 Aug 7;42(3):286-300.e4.
Journal cover image

Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

August 7, 2017

Volume

42

Issue

3

Start / End Page

286 / 300.e4

Location

United States

Related Subject Headings

  • Synaptic Potentials
  • Synapses
  • Signal Transduction
  • Receptors, Somatostatin
  • Neurogenesis
  • Mice
  • Interneurons
  • Developmental Biology
  • Cilia
  • Cells, Cultured