Cellular transduction mechanisms of adeno-associated viral vectors.

Journal Article (Journal Article;Review)

Recombinant adeno-associated viral vectors (rAAV) are regarded as promising vehicles for therapeutic gene delivery. Continued development and new strategies are essential to improve the potency of AAV vectors and reduce the effective dose needed for clinical efficacy. In this regard, many studies have focused on understanding the cellular transduction mechanisms of rAAV, often with the goal of exploiting this knowledge to increase gene transfer efficiency. Here, we provide an overview of our evolving understanding of rAAV cellular trafficking pathways through the host cell, beginning with cellular entry and ending with transcription of the vector genome. Strategies to exploit this information for improving rAAV transduction are discussed.

Full Text

Duke Authors

Cited Authors

  • Berry, GE; Asokan, A

Published Date

  • December 2016

Published In

Volume / Issue

  • 21 /

Start / End Page

  • 54 - 60

PubMed ID

  • 27544821

Pubmed Central ID

  • PMC5138113

Electronic International Standard Serial Number (EISSN)

  • 1879-6265

Digital Object Identifier (DOI)

  • 10.1016/j.coviro.2016.08.001


  • eng

Conference Location

  • Netherlands