Systemic gene transfer to skeletal muscle using reengineered AAV vectors.

Journal Article (Journal Article)

Gene therapy of musculoskeletal disorders warrants efficient gene transfer to a wide range of muscle groups. Reengineered adeno-associated viral (AAV) vectors that selectively transduce muscle tissue following systemic administration are attractive candidates for such applications. Here we provide examples of several lab-derived AAV vectors that display systemic tissue tropism in mice. Methods to evaluate the efficiency of gene transfer to skeletal muscle following intravenous or isolated limb infusion of AAV -vectors in mice are discussed in detail.

Full Text

Duke Authors

Cited Authors

  • Phillips, JL; Hegge, J; Wolff, JA; Samulski, RJ; Asokan, A

Published Date

  • 2011

Published In

Volume / Issue

  • 709 /

Start / End Page

  • 141 - 151

PubMed ID

  • 21194026

Pubmed Central ID

  • PMC3253371

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

Digital Object Identifier (DOI)

  • 10.1007/978-1-61737-982-6_9


  • eng

Conference Location

  • United States