Reengineered AAV vectors: old dog, new tricks.

Journal Article (Journal Article)

Adeno-associated viral (AAV) vectors have emerged in recent years as powerful tools for therapeutic gene transfer. Successes in clinical trials and the discovery of several hundreds of naturally occurring AAV isolates have triggered efforts to understand and manipulate this deceptively simple parvovirus for a myriad of gene therapy applications. Exciting breakthroughs based on directed evolution of novel tissue-specific variants from combinatorial AAV libraries have been reported. Recent approaches driven by the availability of structural information have yielded a new generation of reengineered AAV vectors.

Full Text

Duke Authors

Cited Authors

  • Asokan, A

Published Date

  • May 2010

Published In

Volume / Issue

  • 9 / 48

Start / End Page

  • 399 - 403

PubMed ID

  • 20515607

Pubmed Central ID

  • PMC2900186

Electronic International Standard Serial Number (EISSN)

  • 1944-7930


  • eng

Conference Location

  • United States