Inflammasome, Inflammation, and Tissue Homeostasis.

Journal Article (Journal Article;Review)

Organismal fitness demands proper response to neutralize the threat from infection or injury. At the mammalian intestinal epithelium barrier, the inflammasome coordinates an elaborate tissue repair response marked by the induction of antimicrobial peptides, wound-healing cytokines, and reparative proliferation of epithelial stem cells. The inflammasome in myeloid and intestinal epithelial compartments exerts these effects in part through maintenance of a healthy microbiota. Disease-associated mutations and elevated expression of certain inflammasome sensors have been identified. In many cases, inhibition of inflammasome activity has dramatic effects on disease outcome in mouse models of experimental colitis. Here, we discuss recent studies on the role of distinct inflammasome sensors in intestinal homeostasis and how this knowledge may be translated into a therapeutic setting.

Full Text

Duke Authors

Cited Authors

  • Rathinam, VAK; Chan, FK-M

Published Date

  • March 2018

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 304 - 318

PubMed ID

  • 29433944

Pubmed Central ID

  • PMC6456255

Electronic International Standard Serial Number (EISSN)

  • 1471-499X

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2018.01.004


  • eng

Conference Location

  • England