Inflammasome, Inflammation, and Tissue Homeostasis.
Published
Journal Article (Review)
Organismal fitness demands proper response to neutralize the threat from infection or injury. At the mammalian intestinal epithelium barrier, the inflammasome coordinates an elaborate tissue repair response marked by the induction of antimicrobial peptides, wound-healing cytokines, and reparative proliferation of epithelial stem cells. The inflammasome in myeloid and intestinal epithelial compartments exerts these effects in part through maintenance of a healthy microbiota. Disease-associated mutations and elevated expression of certain inflammasome sensors have been identified. In many cases, inhibition of inflammasome activity has dramatic effects on disease outcome in mouse models of experimental colitis. Here, we discuss recent studies on the role of distinct inflammasome sensors in intestinal homeostasis and how this knowledge may be translated into a therapeutic setting.
Full Text
Duke Authors
Cited Authors
- Rathinam, VAK; Chan, FK-M
Published Date
- March 2018
Published In
Volume / Issue
- 24 / 3
Start / End Page
- 304 - 318
PubMed ID
- 29433944
Pubmed Central ID
- 29433944
Electronic International Standard Serial Number (EISSN)
- 1471-499X
Digital Object Identifier (DOI)
- 10.1016/j.molmed.2018.01.004
Language
- eng
Conference Location
- England