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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Publication ,  Journal Article
Galluzzi, L; Bravo-San Pedro, JM; Vitale, I; Aaronson, SA; Abrams, JM; Adam, D; Alnemri, ES; Altucci, L; Andrews, D; Baehrecke, EH; Bazan, NG ...
Published in: Cell Death Differ
January 2015

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.

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Published In

Cell Death Differ

DOI

EISSN

1476-5403

Publication Date

January 2015

Volume

22

Issue

1

Start / End Page

58 / 73

Location

England

Related Subject Headings

  • Terminology as Topic
  • Signal Transduction
  • Humans
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

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Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., … Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ, 22(1), 58–73. https://doi.org/10.1038/cdd.2014.137
Galluzzi, L., J. M. Bravo-San Pedro, I. Vitale, S. A. Aaronson, J. M. Abrams, D. Adam, E. S. Alnemri, et al. “Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.Cell Death Differ 22, no. 1 (January 2015): 58–73. https://doi.org/10.1038/cdd.2014.137.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan;22(1):58–73.
Galluzzi, L., et al. “Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.Cell Death Differ, vol. 22, no. 1, Jan. 2015, pp. 58–73. Pubmed, doi:10.1038/cdd.2014.137.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin K-M, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon M-L, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine J-C, Martin SJ, Martinou J-C, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon H-U, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan;22(1):58–73.

Published In

Cell Death Differ

DOI

EISSN

1476-5403

Publication Date

January 2015

Volume

22

Issue

1

Start / End Page

58 / 73

Location

England

Related Subject Headings

  • Terminology as Topic
  • Signal Transduction
  • Humans
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences