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The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function.

Publication ,  Journal Article
Chan, FK
Published in: Ann Rheum Dis
November 2000

Signalling by the tumour necrosis factor receptors (TNFR) is thought to be mediated by the binding of the trimeric ligand TNF to three monomeric subunits of the receptor. This ligand induced trimerisation model of TNFR signalling is mainly supported by crystallographic data of the p60 TNFR-1 and TNFbeta complex in which the trimeric ligand interdigitates between the individual receptor chains and prevents the receptor subunits from interacting with each other. Recently, a domain NH(2)-terminal to the ligand binding domain in the extracellular region of p60 TNFR-1, p80 TNFR-2 and Fas was identified that mediates receptor self association before ligand binding. This pre-ligand binding assembly domain or PLAD is critical for assembly of functional receptor complexes on the cell surface and may provide a potential target in the design of future novel therapeutics against diseases mediated by members of the TNFR family of receptors.

Duke Scholars

Published In

Ann Rheum Dis

DOI

ISSN

0003-4967

Publication Date

November 2000

Volume

59 Suppl 1

Issue

Suppl 1

Start / End Page

i50 / i53

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Ligands
  • Humans
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chan, F. K. (2000). The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function. Ann Rheum Dis, 59 Suppl 1(Suppl 1), i50–i53. https://doi.org/10.1136/ard.59.suppl_1.i50
Chan, F. K. “The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function.Ann Rheum Dis 59 Suppl 1, no. Suppl 1 (November 2000): i50–53. https://doi.org/10.1136/ard.59.suppl_1.i50.
Chan, F. K. “The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function.Ann Rheum Dis, vol. 59 Suppl 1, no. Suppl 1, Nov. 2000, pp. i50–53. Pubmed, doi:10.1136/ard.59.suppl_1.i50.

Published In

Ann Rheum Dis

DOI

ISSN

0003-4967

Publication Date

November 2000

Volume

59 Suppl 1

Issue

Suppl 1

Start / End Page

i50 / i53

Location

England

Related Subject Headings

  • Signal Transduction
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Ligands
  • Humans
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services