Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

Published

Journal Article

Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor independent missense mutations in Caspase 10. These encode amino acid substitutions that decrease caspase activity and interfere with death receptor-induced apoptosis, particularly that stimulated by Fas ligand and TRAIL. These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Zheng, L; Lobito, A; Chan, FK; Dale, J; Sneller, M; Yao, X; Puck, JM; Straus, SE; Lenardo, MJ

Published Date

  • July 1999

Published In

Volume / Issue

  • 98 / 1

Start / End Page

  • 47 - 58

PubMed ID

  • 10412980

Pubmed Central ID

  • 10412980

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80605-4

Language

  • eng