Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
Journal Article (Journal Article)
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor independent missense mutations in Caspase 10. These encode amino acid substitutions that decrease caspase activity and interfere with death receptor-induced apoptosis, particularly that stimulated by Fas ligand and TRAIL. These results provide evidence that inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II.
Full Text
Duke Authors
Cited Authors
- Wang, J; Zheng, L; Lobito, A; Chan, FK; Dale, J; Sneller, M; Yao, X; Puck, JM; Straus, SE; Lenardo, MJ
Published Date
- July 9, 1999
Published In
Volume / Issue
- 98 / 1
Start / End Page
- 47 - 58
PubMed ID
- 10412980
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/S0092-8674(00)80605-4
Language
- eng
Conference Location
- United States