Tumor Necrosis Factor Family Ligands and Receptors in the Immune System: Targets for Future Pharmaceuticals.

Journal Article (Journal Article)

Members of the superfamily of ligands related to tumor necrosis factor (TNF) as well as the superfamily of receptors that recognize these ligands play critical roles in various aspects of mammalian lymphocyte development and immune function. Many of the receptors and their cognate ligands have well-known roles in the regulation of cell­cell interactions as well as in the proper development of lymphoid organs, skin and other systems. Disruption of the ligand­receptor interactions within this superfamily of molecules often leads to pathological conditions. Consequently, these are two of the most widely studied and pharmacologically interesting gene families in biology and medicine. The roles of TNF and TNF receptor-like molecules in the immune system are discussed. (c) 2002 Prous Science. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Chan, FK-M; Lenardo, MJ

Published Date

  • October 2002

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 483 - 490

PubMed ID

  • 12677186

International Standard Serial Number (ISSN)

  • 0214-0934

Digital Object Identifier (DOI)

  • 10.1358/dnp.2002.15.8.840068


  • eng

Conference Location

  • United States