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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

Publication ,  Journal Article
Chan, FK; Chun, HJ; Zheng, L; Siegel, RM; Bui, KL; Lenardo, MJ
Published in: Science
June 30, 2000

A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly domain (PLAD) is physically distinct from the domain that forms the major contacts with ligand, but is necessary and sufficient for the assembly of TNFR complexes that bind TNF-alpha and mediate signaling. Other members of the TNFR superfamily, including TRAIL receptor 1 and CD40, show similar homotypic association. Thus, TNFRs and related receptors appear to function as preformed complexes rather than as individual receptor subunits that oligomerize after ligand binding.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 30, 2000

Volume

288

Issue

5475

Start / End Page

2351 / 2354

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tumor Cells, Cultured
  • Succinimides
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Protein Conformation
 

Citation

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Chan, F. K., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000). A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science, 288(5475), 2351–2354. https://doi.org/10.1126/science.288.5475.2351
Chan, F. K., H. J. Chun, L. Zheng, R. M. Siegel, K. L. Bui, and M. J. Lenardo. “A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.Science 288, no. 5475 (June 30, 2000): 2351–54. https://doi.org/10.1126/science.288.5475.2351.
Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000 Jun 30;288(5475):2351–4.
Chan, F. K., et al. “A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.Science, vol. 288, no. 5475, June 2000, pp. 2351–54. Pubmed, doi:10.1126/science.288.5475.2351.
Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000 Jun 30;288(5475):2351–2354.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

June 30, 2000

Volume

288

Issue

5475

Start / End Page

2351 / 2354

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tumor Cells, Cultured
  • Succinimides
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Protein Conformation