Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells


Journal Article

Full Text

Duke Authors

Cited Authors

  • Meyers, RM; Bryan, JG; McFarland, JM; Weir, BA; Sizemore, AE; Xu, H; Dharia, NV; Montgomery, PG; Cowley, GS; Pantel, S; Goodale, A; Lee, Y; Ali, LD; Jiang, G; Lubonja, R; Harrington, WF; Strickland, M; Wu, T; Hawes, DC; Zhivich, VA; Wyatt, MR; Kalani, Z; Chang, JJ; Okamoto, M; Stegmaier, K; Golub, TR; Boehm, JS; Vazquez, F; Root, DE; Hahn, WC; Tsherniak, A

Published Date

  • December 2017

Published In

Volume / Issue

  • 49 / 12

Start / End Page

  • 1779 - 1784

Published By

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.3984


  • en