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Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.

Publication ,  Journal Article
Johnson, AJ; Upshaw, J; Pavelko, KD; Rodriguez, M; Pease, LR
Published in: FASEB J
December 2001

Central nervous system-infiltrating CD8+ T cells are potential mediators of neuropathology in models of multiple sclerosis induced by Theiler's murine encephalomyelitis virus (TMEV) infection. C57BL/6 mice mount a vigorous cytotoxic T lymphocyte (CTL) response against the immunodominant virus peptide VP2121-130 and clear TMEV infection. Interferon-g (IFN-g)R-/- mice also mount a strong CTL response against the VP2121-130 epitope, but because of genetic deficiencies in critical IFN-g signaling pathways, they do not clear TMEV infection and develop prominent neurological deficits within 6 wk. This pronounced disease process, coupled with a defined CTL response, provides an ideal model for evaluating the importance of antiviral CTL activity in the development of severe demyelination and loss of motor neuron function. By administering the VP2121-130 peptide before and during TMEV infection, 99% of the VP2121-130-specific CD8+ T cell response was inhibited. No decrease in virus infection was observed. Peptide treatment did result in significantly less motor dysfunction, even when no differences in levels of demyelination were observed. Although most investigators focus on the role of CD4+ T cells in demyelinating disease, these studies are the first to demonstrate a clear contribution of antiviral CD8+ T cells in neurological injury in a chronic-progressive model of multiple sclerosis.

Duke Scholars

Published In

FASEB J

DOI

EISSN

1530-6860

Publication Date

December 2001

Volume

15

Issue

14

Start / End Page

2760 / 2762

Location

United States

Related Subject Headings

  • Viral Load
  • Theilovirus
  • Receptors, Interferon
  • Motor Activity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Count
  • Leukocytes, Mononuclear
  • Killer Cells, Natural
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Johnson, A. J., Upshaw, J., Pavelko, K. D., Rodriguez, M., & Pease, L. R. (2001). Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J, 15(14), 2760–2762. https://doi.org/10.1096/fj.01-0373fje
Johnson, A. J., J. Upshaw, K. D. Pavelko, M. Rodriguez, and L. R. Pease. “Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.FASEB J 15, no. 14 (December 2001): 2760–62. https://doi.org/10.1096/fj.01-0373fje.
Johnson AJ, Upshaw J, Pavelko KD, Rodriguez M, Pease LR. Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J. 2001 Dec;15(14):2760–2.
Johnson, A. J., et al. “Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.FASEB J, vol. 15, no. 14, Dec. 2001, pp. 2760–62. Pubmed, doi:10.1096/fj.01-0373fje.
Johnson AJ, Upshaw J, Pavelko KD, Rodriguez M, Pease LR. Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J. 2001 Dec;15(14):2760–2762.

Published In

FASEB J

DOI

EISSN

1530-6860

Publication Date

December 2001

Volume

15

Issue

14

Start / End Page

2760 / 2762

Location

United States

Related Subject Headings

  • Viral Load
  • Theilovirus
  • Receptors, Interferon
  • Motor Activity
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Count
  • Leukocytes, Mononuclear
  • Killer Cells, Natural