An Unexpected Finding in SUDEP Involving a Child: Focal Myocardial Infarct Adjacent to Bundle of His.

Journal Article

Sudden unexpected death in epilepsy (SUDEP) is a nontraumatic, nondrowning death of an individual with epilepsy in which an autopsy with appropriate ancillary studies does not identify a cause of death. The mechanism of death in SUDEP is unknown, but is thought to involve cardiac and/or respiratory mechanisms. Research in SUDEP is hindered by a lack of consensus regarding required components of a death investigation before a cause of death may be certified as SUDEP. Histopathologic examination of the cardiac conduction system is not routinely performed in SUDEP death investigations. We present a case of SUDEP where histopathologic examination of the cardiac conduction system revealed a focal myocardial infarct of the summit of the ventricular septum abutting the bundle of His, which potentially provides insight into the mechanism of SUDEP for this particular case, and suggests that routine examination of the cardiac conduction system in SUDEP may be beneficial.

Full Text

Duke Authors

Cited Authors

  • Neff, JL; Lin, PT

Published Date

  • November 2017

Published In

Volume / Issue

  • 62 / 6

Start / End Page

  • 1662 - 1664

PubMed ID

  • 28230913

Electronic International Standard Serial Number (EISSN)

  • 1556-4029

Digital Object Identifier (DOI)

  • 10.1111/1556-4029.13454


  • eng

Conference Location

  • United States