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A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.

Publication ,  Journal Article
Kimbrel, NA; Garrett, ME; Dennis, MF; VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, ; Hauser, MA; Beckham, JC ...
Published in: Psychiatry Res
November 2018

Death by suicide and suicidal behavior are major concerns among U.S. military veterans; however, no genome-wide association studies (GWAS) studies of suicidal behavior have been conducted among U.S. military veterans to date, despite the elevated rate of suicidal behavior observed within this population. Accordingly, the primary objective of the present research was to conduct the first GWAS of suicide attempts and suicidal ideation in a large and well-characterized sample of U.S. military veterans. The gene most significantly associated (p = 9.28 × 10-7) with suicide attempts was the Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2 (KCNMB2) gene, which plays a key role in neuronal excitability. In addition, replication analyses provided additional support for the potential role of the ABI Family Member 3 Binding Protein (ABI3BP) gene in the pathogenesis of suicidal behavior, as numerous nominal associations were found between this gene and both suicide attempts and suicidal ideation. Additional work aimed at replicating and extending these findings is needed.

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Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

November 2018

Volume

269

Start / End Page

64 / 69

Location

Ireland

Related Subject Headings

  • Veterans
  • United States
  • Suicide, Attempted
  • Suicidal Ideation
  • Psychiatry
  • Military Personnel
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
 

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Kimbrel, N. A., Garrett, M. E., Dennis, M. F., VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, ., Hauser, M. A., Ashley-Koch, A. E., & Beckham, J. C. (2018). A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans. Psychiatry Res, 269, 64–69. https://doi.org/10.1016/j.psychres.2018.07.017
Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Michelle F. VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Michael A. Hauser, Allison E. Ashley-Koch, and Jean C. Beckham. “A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.Psychiatry Res 269 (November 2018): 64–69. https://doi.org/10.1016/j.psychres.2018.07.017.
Kimbrel NA, Garrett ME, Dennis MF, VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Hauser MA, Ashley-Koch AE, et al. A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans. Psychiatry Res. 2018 Nov;269:64–9.
Kimbrel, Nathan A., et al. “A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.Psychiatry Res, vol. 269, Nov. 2018, pp. 64–69. Pubmed, doi:10.1016/j.psychres.2018.07.017.
Kimbrel NA, Garrett ME, Dennis MF, VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Hauser MA, Ashley-Koch AE, Beckham JC. A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans. Psychiatry Res. 2018 Nov;269:64–69.
Journal cover image

Published In

Psychiatry Res

DOI

EISSN

1872-7123

Publication Date

November 2018

Volume

269

Start / End Page

64 / 69

Location

Ireland

Related Subject Headings

  • Veterans
  • United States
  • Suicide, Attempted
  • Suicidal Ideation
  • Psychiatry
  • Military Personnel
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study