Regulation of Division and Differentiation of Plant Stem Cells.

Published

Journal Article

A major challenge in developmental biology is unraveling the precise regulation of plant stem cell maintenance and the transition to a fully differentiated cell. In this review, we highlight major themes coordinating the acquisition of cell identity and subsequent differentiation in plants. Plant cells are immobile and establish position-dependent cell lineages that rely heavily on external cues. Central players are the hormones auxin and cytokinin, which balance cell division and differentiation during organogenesis. Transcription factors and miRNAs, many of which are mobile in plants, establish gene regulatory networks that communicate cell position and fate. Small peptide signaling also provides positional cues as new cell types emerge from stem cell division and progress through differentiation. These pathways recruit similar players for patterning different organs, emphasizing the modular nature of gene regulatory networks. Finally, we speculate on the outstanding questions in the field and discuss how they may be addressed by emerging technologies.

Full Text

Duke Authors

Cited Authors

  • Pierre-Jerome, E; Drapek, C; Benfey, PN

Published Date

  • October 2018

Published In

Volume / Issue

  • 34 /

Start / End Page

  • 289 - 310

PubMed ID

  • 30134119

Pubmed Central ID

  • 30134119

Electronic International Standard Serial Number (EISSN)

  • 1530-8995

International Standard Serial Number (ISSN)

  • 1081-0706

Digital Object Identifier (DOI)

  • 10.1146/annurev-cellbio-100617-062459

Language

  • eng