The Use of Antidepressants in Bipolar Depression.


Journal Article

Depression remains a significant debilitating and frequent phase of illness for patients with bipolar disorder. There are few FDA-approved medications for its treatment, only one of which includes a traditional antidepressant (olanzapine-fluoxetine combination), despite studies that demonstrate traditional antidepressants are one of the most commonly prescribed class of medications for bipolar patients in a depressive episode. While traditional antidepressants remain the primary option for treatment of unipolar depression, their use in bipolar depression has been controversial due to a limited efficacy evidence and the concern for potential harm. This chapter reviews the current data concerning the use of traditional antidepressants in bipolar disorder, and the current expert treatment guideline recommendations for their use.

Full Text

Duke Authors

Cited Authors

  • Beyer, JL

Published Date

  • 2019

Published In

Volume / Issue

  • 250 /

Start / End Page

  • 415 - 442

PubMed ID

  • 30141097

Pubmed Central ID

  • 30141097

International Standard Serial Number (ISSN)

  • 0171-2004

Digital Object Identifier (DOI)

  • 10.1007/164_2018_155


  • eng

Conference Location

  • Germany