SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta-analysis.


Journal Article

BACKGROUND:Brugada syndrome (BrS) is an inherited arrhythmic disease linked to SCN5A mutations. It is controversial whether SCN5A mutation carriers possess a greater risk of major arrhythmic events (MAE). We examined the association of SCN5A mutations and MAE in BrS patients. METHODS:We comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Included studies were published cohort and case-control studies that compared MAE in BrS patients with and without SCN5A mutations. Data from each study were combined using the random-effects model. Generic inverse variance method of DerSimonian and Laird was employed to calculate the risk ratios (RR) and 95% confidence intervals (CI). RESULTS:Seven studies from March 2002 to October 2017 were included (1,049 BrS subjects). SCN5A mutations were associated with MAE in Asian populations (RR = 2.03, 95% CI: 1.37-3.00, p = 0.0004, I2  = 0.0%), patients who were symptomatic (RR = 2.66, 95% CI: 1.62-4.36, p = 0.0001, I2  = 23.0%), and individuals with spontaneous type-1 Brugada pattern (RR = 1.84, 95% CI: 1.05-3.23, p = 0.03, I2  = 0.0%). CONCLUSIONS:SCN5A mutations in BrS increase the risk of MAE in Asian populations, symptomatic BrS patients, and individuals with spontaneous type-1 Brugada pattern. Our study suggests that SCN5A mutation status should be an important tool for risk assessment in BrS patients.

Full Text

Duke Authors

Cited Authors

  • Rattanawong, P; Chenbhanich, J; Mekraksakit, P; Vutthikraivit, W; Chongsathidkiet, P; Limpruttidham, N; Prasitlumkum, N; Chung, EH

Published Date

  • January 2019

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • e12589 -

PubMed ID

  • 30126015

Pubmed Central ID

  • 30126015

Electronic International Standard Serial Number (EISSN)

  • 1542-474X

International Standard Serial Number (ISSN)

  • 1082-720X

Digital Object Identifier (DOI)

  • 10.1111/anec.12589


  • eng