Power in numbers.

Journal Article (Journal Article)

Collecting useful data on a sufficiently large cohort of pregnancies in women with rheumatic disease is a challenge. The original manuscripts that demonstrated the dangers of pregnancy in women with lupus were relatively small case series. As larger prospective cohorts were collected by university-based experts, however, greater safety was demonstrated and the current norms of treatment were determined. In recent years, larger administrative databases have been tapped to study pregnancies not managed within university clinics and to study the long-term impact of maternal rheumatic disease on the offspring. Each of these methods of study has both strengths and weaknesses, adding a unique piece of data to our overall knowledge. We will discuss a range of approaches to the study of rheumatic disease in pregnancy, covering the potential benefits that each brings as well as the biases that can impact study results. When the results of studies are viewed through these lenses, each can contribute to our larger understanding of the rheumatic diseases in pregnancy.

Full Text

Duke Authors

Cited Authors

  • Vinet, E; Chakravarty, EF; Clowse, MEB

Published Date

  • July 1, 2018

Published In

Volume / Issue

  • 57 / suppl_5

Start / End Page

  • v40 - v47

PubMed ID

  • 30137590

Pubmed Central ID

  • 30137590

Electronic International Standard Serial Number (EISSN)

  • 1462-0332

Digital Object Identifier (DOI)

  • 10.1093/rheumatology/key111


  • eng

Conference Location

  • England