Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.


Journal Article (Review)

There is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF outcomes from several antihyperglycemic therapies. The absence of well-powered randomized controlled studies has resulted in significant treatment variations in the glycemic management in patients with coexisting diabetes and HF. However, there is emerging evidence from recent clinical trials suggesting that sodium-glucose-co-transporter-2 inhibitors may be used as a therapy to improve HF outcomes. In order to understand the current state of knowledge, we reviewed the evolving evidence of antihyperglycemic therapies and present strategies to optimize these therapies in patients with diabetes and HF. This analysis is based on discussions among scientists, clinical trialists, industry sponsors, and regulatory representatives who attended the 12th Global Cardiovascular Clinical Trialists Forum, Washington, DC, December 1 to 3, 2016.

Full Text

Duke Authors

Cited Authors

  • Sharma, A; Cooper, LB; Fiuzat, M; Mentz, RJ; Ferreira, JP; Butler, J; Fitchett, D; Moses, AC; O'Connor, C; Zannad, F

Published Date

  • October 2018

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • 813 - 822

PubMed ID

  • 30098964

Pubmed Central ID

  • 30098964

Electronic International Standard Serial Number (EISSN)

  • 2213-1787

Digital Object Identifier (DOI)

  • 10.1016/j.jchf.2018.05.020


  • eng

Conference Location

  • United States