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Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.

Publication ,  Journal Article
Sharma, A; Cooper, LB; Fiuzat, M; Mentz, RJ; Ferreira, JP; Butler, J; Fitchett, D; Moses, AC; O'Connor, C; Zannad, F
Published in: JACC Heart Fail
October 2018

There is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF outcomes from several antihyperglycemic therapies. The absence of well-powered randomized controlled studies has resulted in significant treatment variations in the glycemic management in patients with coexisting diabetes and HF. However, there is emerging evidence from recent clinical trials suggesting that sodium-glucose-co-transporter-2 inhibitors may be used as a therapy to improve HF outcomes. In order to understand the current state of knowledge, we reviewed the evolving evidence of antihyperglycemic therapies and present strategies to optimize these therapies in patients with diabetes and HF. This analysis is based on discussions among scientists, clinical trialists, industry sponsors, and regulatory representatives who attended the 12th Global Cardiovascular Clinical Trialists Forum, Washington, DC, December 1 to 3, 2016.

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Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

October 2018

Volume

6

Issue

10

Start / End Page

813 / 822

Location

United States

Related Subject Headings

  • Hypoglycemic Agents
  • Humans
  • Heart Failure
  • Diabetes Mellitus, Type 2
  • Diabetes Complications
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Sharma, A., Cooper, L. B., Fiuzat, M., Mentz, R. J., Ferreira, J. P., Butler, J., … Zannad, F. (2018). Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus. JACC Heart Fail, 6(10), 813–822. https://doi.org/10.1016/j.jchf.2018.05.020
Sharma, Abhinav, Lauren B. Cooper, Mona Fiuzat, Robert J. Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O’Connor, and Faiez Zannad. “Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.JACC Heart Fail 6, no. 10 (October 2018): 813–22. https://doi.org/10.1016/j.jchf.2018.05.020.
Sharma A, Cooper LB, Fiuzat M, Mentz RJ, Ferreira JP, Butler J, et al. Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus. JACC Heart Fail. 2018 Oct;6(10):813–22.
Sharma, Abhinav, et al. “Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.JACC Heart Fail, vol. 6, no. 10, Oct. 2018, pp. 813–22. Pubmed, doi:10.1016/j.jchf.2018.05.020.
Sharma A, Cooper LB, Fiuzat M, Mentz RJ, Ferreira JP, Butler J, Fitchett D, Moses AC, O’Connor C, Zannad F. Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus. JACC Heart Fail. 2018 Oct;6(10):813–822.
Journal cover image

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

October 2018

Volume

6

Issue

10

Start / End Page

813 / 822

Location

United States

Related Subject Headings

  • Hypoglycemic Agents
  • Humans
  • Heart Failure
  • Diabetes Mellitus, Type 2
  • Diabetes Complications
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology