Biology of Coagulation and Coagulopathy in Neurologic Surgery.

Journal Article (Journal Article;Review)

Hemostasis is a cell-based process that is regulated in a tissue-specific manner by the differential expression of procoagulant and anticoagulant factors on endothelial cells from different sites throughout the vasculature. The central nervous system, in particular, exhibits unique mechanisms of hemostatic regulation that favor increased activity of the tissue factor pathway. This results in an unusually high degree of protection against hemorrhage, at the potential expense of increased thrombotic risk. Unfortunately, standard laboratory assays, including the PT and aPTT, do not accurately reflect the complexity of hemostasis in vivo; therefore, they cannot predict the risk of bleeding or thrombosis.

Full Text

Duke Authors

Cited Authors

  • Fager, AM; Hoffman, M

Published Date

  • October 2018

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 475 - 483

PubMed ID

  • 30223960

Electronic International Standard Serial Number (EISSN)

  • 1558-1349

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • United States