Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways.


Journal Article (Review)

In metazoans, thousands of intracellular proteins are modified with O-linked β-N-acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In particular, a complex and evolutionarily conserved interplay between O-GlcNAcylation and oxidative stress has emerged in recent years. Here, we review the current literature on the connections between O-GlcNAc and oxidative stress, with a particular emphasis on major signaling pathways, such as KEAP1/NRF2, FOXO, NFκB, p53 and cell metabolism. Taken together, this work sheds important light on the signaling functions of protein glycosylation and the mechanisms of stress responses alike and illuminates how the two are integrated in animal cell physiology.

Full Text

Duke Authors

Cited Authors

  • Chen, P-H; Chi, J-T; Boyce, M

Published Date

  • August 1, 2018

Published In

Volume / Issue

  • 28 / 8

Start / End Page

  • 556 - 564

PubMed ID

  • 29548027

Pubmed Central ID

  • 29548027

Electronic International Standard Serial Number (EISSN)

  • 1460-2423

Digital Object Identifier (DOI)

  • 10.1093/glycob/cwy027


  • eng

Conference Location

  • England