Diagnostic Approach to Health Care- and Device-Associated Central Nervous System Infections.

Journal Article (Journal Article;Review)

Health care- and device-associated central nervous system (CNS) infections have a distinct epidemiology, pathophysiology, and microbiology that require a unique diagnostic approach. Most clinical signs, symptoms, and tests used to diagnose community-acquired CNS infections are insensitive and nonspecific in neurosurgical patients due to postsurgical changes, invasive devices, prior antimicrobial exposure, and underlying CNS disease. The lack of a standardized definition of infection or diagnostic pathway has added to this challenge. In this review, we summarize the epidemiology, microbiology, and clinical presentation of these infections, discuss the issues with existing microbiologic tests, and give an overview of the current diagnostic approach.

Full Text

Duke Authors

Cited Authors

  • Martin, RM; Zimmermann, LL; Huynh, M; Polage, CR

Published Date

  • November 2018

Published In

Volume / Issue

  • 56 / 11

PubMed ID

  • 30135235

Pubmed Central ID

  • PMC6204668

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.00861-18


  • eng

Conference Location

  • United States