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Automated Deep Brain Stimulation Programming for Tremor.

Publication ,  Journal Article
Haddock, A; Mitchell, KT; Miller, A; Ostrem, JL; Chizeck, HJ; Miocinovic, S
Published in: IEEE Trans Neural Syst Rehabil Eng
August 2018

Deep brain stimulation (DBS) programming, the systematic selection of fixed electrical stimulation parameters that deliver maximal therapeutic benefit while limiting side effects, poses several challenges in the treatment of movement disorders. DBS programming requires the expertise of trained neurologists or nurses who assess patient symptoms according to standardized clinical rating scales and use patient reports of DBS-related side effects to adjust stimulation parameters and optimize therapy. In this paper, we describe and validate an automated software platform for DBS programming for tremor associated with Parkinson's disease and essential tremor. DBS parameters are changed automatically through a direct computer interface with implanted neurostimulators. Each tested DBS setting is ranked according to its effect on tremor, which is assessed using smartwatch inertial measurement unit data, and side effects, which are reported through a user interface. Blinded neurologist assessments showed the automated programming method performed at least as well as clinician mediated programming in selecting the optimal settings for tremor therapy. This proof of concept study describes a novel DBS programming paradigm that may improve programming efficiency and outcomes, increase access to programming outside specialty clinics, and aid in the development of adaptive and closed-loop DBS strategies.

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Published In

IEEE Trans Neural Syst Rehabil Eng

DOI

EISSN

1558-0210

Publication Date

August 2018

Volume

26

Issue

8

Start / End Page

1618 / 1625

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Software
  • Pilot Projects
  • Parkinson Disease
  • Middle Aged
  • Male
  • Humans
  • Female
  • Essential Tremor
  • Deep Brain Stimulation
 

Citation

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Haddock, A., Mitchell, K. T., Miller, A., Ostrem, J. L., Chizeck, H. J., & Miocinovic, S. (2018). Automated Deep Brain Stimulation Programming for Tremor. IEEE Trans Neural Syst Rehabil Eng, 26(8), 1618–1625. https://doi.org/10.1109/TNSRE.2018.2852222
Haddock, Andrew, Kyle T. Mitchell, Andrew Miller, Jill L. Ostrem, Howard J. Chizeck, and Svjetlana Miocinovic. “Automated Deep Brain Stimulation Programming for Tremor.IEEE Trans Neural Syst Rehabil Eng 26, no. 8 (August 2018): 1618–25. https://doi.org/10.1109/TNSRE.2018.2852222.
Haddock A, Mitchell KT, Miller A, Ostrem JL, Chizeck HJ, Miocinovic S. Automated Deep Brain Stimulation Programming for Tremor. IEEE Trans Neural Syst Rehabil Eng. 2018 Aug;26(8):1618–25.
Haddock, Andrew, et al. “Automated Deep Brain Stimulation Programming for Tremor.IEEE Trans Neural Syst Rehabil Eng, vol. 26, no. 8, Aug. 2018, pp. 1618–25. Pubmed, doi:10.1109/TNSRE.2018.2852222.
Haddock A, Mitchell KT, Miller A, Ostrem JL, Chizeck HJ, Miocinovic S. Automated Deep Brain Stimulation Programming for Tremor. IEEE Trans Neural Syst Rehabil Eng. 2018 Aug;26(8):1618–1625.

Published In

IEEE Trans Neural Syst Rehabil Eng

DOI

EISSN

1558-0210

Publication Date

August 2018

Volume

26

Issue

8

Start / End Page

1618 / 1625

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Software
  • Pilot Projects
  • Parkinson Disease
  • Middle Aged
  • Male
  • Humans
  • Female
  • Essential Tremor
  • Deep Brain Stimulation