Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.

Journal Article (Journal Article)

We present this case to review the metabolism of oxycodone and the effects of end-stage renal disease on the elimination of oxycodone and its metabolites. A 42-year-old female with end-stage renal disease who was dependent on hemodialysis presented for left hamstring posterior capsule release. She had been receiving methadone for 2 years for chronic leg pain. On postoperative day 1, the patient's medication was changed from IV hydromorphone to oral oxycodone to treat breakthrough pain. By the next day, the patient was unarousable with notable respiratory depression. She did not fully recover after urgent hemodialysis but did have full recovery after receiving an IV naloxone infusion for 22 hours. Further study of the safety of oxycodone in hemodialysis patients is warranted.

Full Text

Duke Authors

Cited Authors

  • Tran, BW; Kohan, LR; Vorenkamp, KE

Published Date

  • February 15, 2015

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 44 - 46

PubMed ID

  • 25689360

Electronic International Standard Serial Number (EISSN)

  • 2325-7237

Digital Object Identifier (DOI)

  • 10.1213/XAA.0000000000000115


  • eng

Conference Location

  • United States