A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

Published

Journal Article

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.

Full Text

Duke Authors

Cited Authors

  • Luo, X; Ikeda, Y; Parker, KL

Published Date

  • May 20, 1994

Published In

Volume / Issue

  • 77 / 4

Start / End Page

  • 481 - 490

PubMed ID

  • 8187173

Pubmed Central ID

  • 8187173

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(94)90211-9

Language

  • eng

Conference Location

  • United States