The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function.

Published

Journal Article

The cytochrome P450 steroid hydroxylases exhibit tissue-specific and developmentally regulated gene expression. Recent studies showed that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays a key role in their gene regulation. In mouse embryos, SF-1 expression began at the inception of adrenal and gonadal development, suggesting that SF-1 plays a key role in the steroidogenic cell differentiation. SF-1 was also expressed in the developing pituitary gland and diencephalon, which raised the possibility that it also has additional roles in endocrine development. To examine the role of SF-1 in intact mice, we disrupted the gene encoding SF-1 by homologous recombination in embryonic stem cells; this approach ultimately permitted us to generate SF-1 knockout mice in which the gene encoding SF-1 was inactivated. These studies revealed essential roles of SF-1 in endocrine development that included adrenal and gonadal development, expression of several markers of pituitary gonadotropes, and formation of the ventromedial hypothalamic (VMH) nucleus. These results indicate that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence.

Full Text

Duke Authors

Cited Authors

  • Luo, X; Ikeda, Y; Parker, KL

Published Date

  • November 1995

Published In

Volume / Issue

  • 350 / 1333

Start / End Page

  • 279 - 283

PubMed ID

  • 8570692

Pubmed Central ID

  • 8570692

Electronic International Standard Serial Number (EISSN)

  • 1471-2970

International Standard Serial Number (ISSN)

  • 0962-8436

Digital Object Identifier (DOI)

  • 10.1098/rstb.1995.0162

Language

  • eng