A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.

Published

Journal Article

Recent analyses of the cytochrome P450 steroid hydroxylases have established a key role for an orphan nuclear receptor, designated steroidogenic factor 1 (SF-1), in their coordinate, cell-selective expression. SF-1 was proposed to regulate the steroid hydroxylases by interacting with shared promoter elements in their 5'-flanking regions. During mouse embryonic development, SF-1 was expressed from the earliest stages of organogenesis of the steroidogenic tissues, suggesting a key role in steroidogenic cell differentiation. Finally, disruption of the gene encoding SF-1 revealed its essential function in the development of the adrenal glands and gonads and in pituitary gonadotrope function. These studies suggest that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence.

Full Text

Duke Authors

Cited Authors

  • Luo, X; Ikeda, Y; Lala, DS; Baity, LA; Meade, JC; Parker, KL

Published Date

  • February 1995

Published In

Volume / Issue

  • 21 / 1-2

Start / End Page

  • 517 - 524

PubMed ID

  • 7588417

Pubmed Central ID

  • 7588417

International Standard Serial Number (ISSN)

  • 0743-5800

Language

  • eng

Conference Location

  • England