The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.
Journal Article (Journal Article)
The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Müllerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.
Full Text
Duke Authors
Cited Authors
- Ikeda, Y; Luo, X; Abbud, R; Nilson, JH; Parker, KL
Published Date
- April 1995
Published In
Volume / Issue
- 9 / 4
Start / End Page
- 478 - 486
PubMed ID
- 7659091
International Standard Serial Number (ISSN)
- 0888-8809
Digital Object Identifier (DOI)
- 10.1210/mend.9.4.7659091
Language
- eng
Conference Location
- United States