Steroidogenic factor 1 is the essential transcript of the mouse Ftz-F1 gene.

Published

Journal Article

Targeted disruption of the mouse Ftz-F1 gene, which encodes the orphan nuclear receptors steroidogenic factor 1 (SF-1) and embryonal long terminal repeat-binding protein (ELP), established that this gene is essential for development of the primary steroidogenic tissues and for male sexual differentiation. Associated with these dramatic developmental abnormalities, all Ftz-F1-disrupted mice died in the immediate postnatal period and had very low glucocorticoid levels. In this report, we show that treatment with corticosteroids markedly prolonged survival of the Ftz-F1-disrupted mice, proving that steroid hormone deficiency causes their death. We also generated SF-1-specific knockout mice with a targeting construct that specifically disrupted the SF-1 coding sequence without impairing the ELP protein. The phenotype of the SF-1-specific knockout mice was indistinguishable from that observed in Ftz-F1-disrupted mice that lack both SF-1 and ELP. Taken together, these results indicate that SF-1 is the Ftz-F1-encoded protein that is required for multiple aspects of endocrine development and for postnatal survival.

Full Text

Duke Authors

Cited Authors

  • Luo, X; Ikeda, Y; Schlosser, DA; Parker, KL

Published Date

  • September 1995

Published In

Volume / Issue

  • 9 / 9

Start / End Page

  • 1233 - 1239

PubMed ID

  • 7491115

Pubmed Central ID

  • 7491115

Electronic International Standard Serial Number (EISSN)

  • 1944-9917

International Standard Serial Number (ISSN)

  • 0888-8809

Digital Object Identifier (DOI)

  • 10.1210/mend.9.9.7491115

Language

  • eng