Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.

Journal Article (Journal Article)

Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in Staphylococcus aureus on media supplemented with fatty acids. The addition of anteiso-fatty acids (1 mM) plus lipoic acid supports normal growth of ΔaccD strains, but supplementation with mammalian fatty acids was less efficient. Mice infected with strain RN6930 developed bacteremia, but bacteria were not detected in mice infected with its ΔaccD derivative. S. aureus bacteria lacking acetyl-CoA carboxylase can be propagated in vitro but were unable to proliferate in mice, suggesting that the acquisition of inactivating mutations in this enzyme is not a mechanism for the evasion of fatty acid synthesis inhibitors.

Full Text

Duke Authors

Cited Authors

  • Parsons, JB; Frank, MW; Rosch, JW; Rock, CO

Published Date

  • November 2013

Published In

Volume / Issue

  • 57 / 11

Start / End Page

  • 5729 - 5732

PubMed ID

  • 23979734

Pubmed Central ID

  • PMC3811263

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/aac.01038-13


  • eng