Culture-negative prosthetic valve endocarditis with concomitant septicemia due to a nontoxigenic Corynebacterium diphtheriae biotype gravis isolate in a patient with multiple risk factors.

Journal Article (Journal Article)

A 54-year-old female with a prosthetic mitral valve presented with a 3-day history of dizziness, subjective fever, and chills. Blood cultures were positive for a pleomorphic Gram-positive rod. Initial phenotypic testing could only support the identification of a Corynebacterium species. Nucleic acid sequencing (16S rRNA) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) were conclusive for Corynebacterium diphtheriae. Definitive phenotypic testing classified the strain as nontoxigenic C. diphtheriae biotype Gravis.

Full Text

Duke Authors

Cited Authors

  • Clinton, LK; Bankowski, MJ; Shimasaki, T; Sae-Ow, W; Whelen, AC; O'Connor, N; Kim, W; Young, R

Published Date

  • November 2013

Published In

Volume / Issue

  • 51 / 11

Start / End Page

  • 3900 - 3902

PubMed ID

  • 24006007

Pubmed Central ID

  • PMC3889795

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.01403-13


  • eng

Conference Location

  • United States