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Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.

Publication ,  Journal Article
Wang, LA; Smith, PB; Laughon, M; Goldberg, RN; Ku, LC; Zimmerman, KO; Balevic, S; Clark, RH; Benjamin, DK; Greenberg, RG ...
Published in: Early Hum Dev
October 2018

BACKGROUND: At very high doses, furosemide is linked to ototoxicity in adults, but little is known about the risk of hearing loss in premature infants exposed to furosemide. AIMS: Evaluate the association between prolonged furosemide exposure and abnormal hearing screening in premature infants. STUDY DESIGN: Using propensity scoring, infants with prolonged (≥28 days) exposure to furosemide were matched to infants never exposed. The matched sample was used to estimate the impact of prolonged furosemide exposure on the probability of an abnormal hearing screen prior to hospital discharge. SUBJECTS: A cohort of infants 501-1250 g birth weight and 23-29 weeks gestational age discharged home from 210 neonatal intensive care units in the United States (2004-2013). OUTCOME MEASURES: We defined abnormal hearing screen as a result of either "fail" or "refer" for either ear. RESULTS: Altogether, 1020 infants exposed to furosemide for ≥28 days were matched to 790 unique infants never exposed, yielding a total of 1042 matches due to sampling with replacement and propensity score ties. Matching resulted in a population similar in baseline characteristics. After adjusting for covariates, the proportion of infants with an abnormal hearing screen in the furosemide-exposed group was not significantly higher than the never-exposed group (absolute difference 3.0% [95% CI -0.2-6.2%], P = 0.07). CONCLUSIONS: Prolonged furosemide exposure was associated with a positive, but not statistically significant, difference in abnormal hearing screening in premature infants. Additional studies with post-hospital discharge audiology follow-up are needed to further evaluate the safety of furosemide in this population.

Duke Scholars

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

October 2018

Volume

125

Start / End Page

26 / 30

Location

Ireland

Related Subject Headings

  • Pregnancy
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Hearing Tests
  • Hearing Loss
  • Gestational Age
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, L. A., Smith, P. B., Laughon, M., Goldberg, R. N., Ku, L. C., Zimmerman, K. O., … Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee, . (2018). Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants. Early Hum Dev, 125, 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009
Wang, Laura A., P Brian Smith, Matthew Laughon, Ronald N. Goldberg, Lawrence C. Ku, Kanecia O. Zimmerman, Stephen Balevic, et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.Early Hum Dev 125 (October 2018): 26–30. https://doi.org/10.1016/j.earlhumdev.2018.08.009.
Wang LA, Smith PB, Laughon M, Goldberg RN, Ku LC, Zimmerman KO, et al. Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants. Early Hum Dev. 2018 Oct;125:26–30.
Wang, Laura A., et al. “Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.Early Hum Dev, vol. 125, Oct. 2018, pp. 26–30. Pubmed, doi:10.1016/j.earlhumdev.2018.08.009.
Wang LA, Smith PB, Laughon M, Goldberg RN, Ku LC, Zimmerman KO, Balevic S, Clark RH, Benjamin DK, Greenberg RG, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants. Early Hum Dev. 2018 Oct;125:26–30.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

October 2018

Volume

125

Start / End Page

26 / 30

Location

Ireland

Related Subject Headings

  • Pregnancy
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Hearing Tests
  • Hearing Loss
  • Gestational Age