Scholars@Duke publication: Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.

Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.

Publication , Journal Article

Weinberg, A; Popmihajlov, Z; Schmader, KE; Johnson, MJ; Caldas, Y; Salazar, AT; Canniff, J; McCarson, BJ; Martin, J; Pang, L; Levin, MJ

Published in: J Infect Dis

January 7, 2019

Published version (DOI) Link to item

Protection against zoster conferred by zoster vaccine live (ZVL; Zostavax) wanes over time. We compared varicella-zoster virus cell-mediated immunity (VZV-CMI) of adults ≥70 years who received a second dose of ZVL ≥10 years after the initial dose with de novo-immunized age-matched controls. Before and during the first year after vaccination, VZV-CMI was significantly higher in reimmunized compared with de novo vaccinees. At 3 years, VZV-CMI differences between groups decreased and only memory responses remained marginally higher in reimmunized participants. In conclusion, the increase in VZV-CMI generated by reimmunization with ZVL is at least equally persistent compared with de novo immunization.

Duke Scholars

Author Kenneth Edwin Schmader Medicine, Geriatrics

Published In

J Infect Dis

DOI

10.1093/infdis/jiy514

EISSN

1537-6613

Publication Date

January 7, 2019

Volume

219

Issue

Start / End Page

335 / 338

Location

United States

Related Subject Headings

Vaccines, Attenuated
Vaccination
Microbiology
Male
Interleukin-2
Interferon-gamma
Immunologic Memory
Immunity, Cellular
Humans
Herpesvirus 3, Human

Citation

APA

Chicago

ICMJE

MLA

NLM

Weinberg, A., Popmihajlov, Z., Schmader, K. E., Johnson, M. J., Caldas, Y., Salazar, A. T., … Levin, M. J. (2019). Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine. J Infect Dis, 219(2), 335–338. https://doi.org/10.1093/infdis/jiy514

Weinberg, Adriana, Zoran Popmihajlov, Kenneth E. Schmader, Michael J. Johnson, Yupanqui Caldas, Adriana Tovar Salazar, Jennifer Canniff, et al. “Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.” J Infect Dis 219, no. 2 (January 7, 2019): 335–38. https://doi.org/10.1093/infdis/jiy514.

Weinberg A, Popmihajlov Z, Schmader KE, Johnson MJ, Caldas Y, Salazar AT, et al. Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine. J Infect Dis. 2019 Jan 7;219(2):335–8.

Weinberg, Adriana, et al. “Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.” J Infect Dis, vol. 219, no. 2, Jan. 2019, pp. 335–38. Pubmed, doi:10.1093/infdis/jiy514.

Weinberg A, Popmihajlov Z, Schmader KE, Johnson MJ, Caldas Y, Salazar AT, Canniff J, McCarson BJ, Martin J, Pang L, Levin MJ. Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine. J Infect Dis. 2019 Jan 7;219(2):335–338.