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Enhanced Drug Delivery to the Skin Using Liposomes.

Publication ,  Journal Article
Blueschke, G; Boico, A; Negussie, AH; Yarmolenko, P; Wood, BJ; Spasojevic, I; Fan, P; Erdmann, D; Schroeder, T; Sauerbier, M; Klitzman, B
Published in: Plast Reconstr Surg Glob Open
July 2018

BACKGROUND: Enhancing drug delivery to the skin has importance in many therapeutic strategies. In particular, the outcome in vascularized composite allotransplantation mainly depends on systemic immunosuppression to prevent and treat episodes of transplant rejection. However, the side effects of systemic immunosuppression may introduce substantial risk to the patient and are weighed against the expected benefits. Successful enhancement of delivery of immunosuppressive agents to the most immunogenic tissues would allow for a reduction in systemic doses, thereby minimizing side effects. Nanoparticle-assisted transport by low temperature-sensitive liposomes (LTSLs) has shown some benefit in anticancer therapy. Our goal was to test whether delivery of a marker agent to the skin could be selectively enhanced. METHODS: In an in vivo model, LTSLs containing doxorubicin (dox) as a marker were administered intravenously to rats that were exposed locally to mild hyperthermia. Skin samples of the hyperthermia treated hind limb were compared with skin of the contralateral normothermia hind limb. Tissue content of dox was quantified both via high-performance liquid chromatography and via histology in skin and liver. RESULTS: The concentration of dox in hyperthermia-treated skin was significantly elevated over both normothermic skin and liver. (P < 0.02). CONCLUSIONS: We show here that delivery of therapeutics to the skin can be targeted and enhanced using LTSLs. Targeting drug delivery with this method may reduce the systemic toxicity seen in a systemic free-drug administration. Development of more hydrophilic immunosuppressants in the future would increase the applicability of this system in the treatment of rejection reactions in vascularized composite allotransplantation. The treatment of other skin condition might be another potential application.

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Published In

Plast Reconstr Surg Glob Open

DOI

ISSN

2169-7574

Publication Date

July 2018

Volume

6

Issue

7

Start / End Page

e1739

Location

United States

Related Subject Headings

  • 3213 Paediatrics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
MLA
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Blueschke, G., Boico, A., Negussie, A. H., Yarmolenko, P., Wood, B. J., Spasojevic, I., … Klitzman, B. (2018). Enhanced Drug Delivery to the Skin Using Liposomes. Plast Reconstr Surg Glob Open, 6(7), e1739. https://doi.org/10.1097/GOX.0000000000001739
Blueschke, Gert, Alina Boico, Ayele H. Negussie, Pavel Yarmolenko, Bradford J. Wood, Ivan Spasojevic, Ping Fan, et al. “Enhanced Drug Delivery to the Skin Using Liposomes.Plast Reconstr Surg Glob Open 6, no. 7 (July 2018): e1739. https://doi.org/10.1097/GOX.0000000000001739.
Blueschke G, Boico A, Negussie AH, Yarmolenko P, Wood BJ, Spasojevic I, et al. Enhanced Drug Delivery to the Skin Using Liposomes. Plast Reconstr Surg Glob Open. 2018 Jul;6(7):e1739.
Blueschke, Gert, et al. “Enhanced Drug Delivery to the Skin Using Liposomes.Plast Reconstr Surg Glob Open, vol. 6, no. 7, July 2018, p. e1739. Pubmed, doi:10.1097/GOX.0000000000001739.
Blueschke G, Boico A, Negussie AH, Yarmolenko P, Wood BJ, Spasojevic I, Fan P, Erdmann D, Schroeder T, Sauerbier M, Klitzman B. Enhanced Drug Delivery to the Skin Using Liposomes. Plast Reconstr Surg Glob Open. 2018 Jul;6(7):e1739.

Published In

Plast Reconstr Surg Glob Open

DOI

ISSN

2169-7574

Publication Date

July 2018

Volume

6

Issue

7

Start / End Page

e1739

Location

United States

Related Subject Headings

  • 3213 Paediatrics
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences