Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal Article (Journal Article;Review)

Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in the retina in both AD and AMD. While current diagnostic modalities for detecting Aβ in the brain are costly or invasive, Aβ in the retina can be noninvasively and conveniently imaged using modern photonic imaging systems such as optical coherence tomography (OCT). Moreover, since many of these retinal changes occur before degenerative changes can be detected in the brain, ocular amyloid biomarkers could be utilized to detect AD as well as AMD in their earliest stages when therapy may be most effective in halting disease progression. Novel technologies to quantify retinal biomarkers have the potential to facilitate early diagnosis and noninvasive monitoring of disease progression with important therapeutic implications.

Full Text

Duke Authors

Cited Authors

  • Ong, SS; Proia, AD; Whitson, HE; Farsiu, S; Doraiswamy, PM; Lad, EM

Published Date

  • July 2019

Published In

Volume / Issue

  • 266 / 7

Start / End Page

  • 1566 - 1577

PubMed ID

  • 30155741

Electronic International Standard Serial Number (EISSN)

  • 1432-1459

Digital Object Identifier (DOI)

  • 10.1007/s00415-018-9028-z


  • eng

Conference Location

  • Germany