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Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Publication ,  Journal Article
Ong, SS; Proia, AD; Whitson, HE; Farsiu, S; Doraiswamy, PM; Lad, EM
Published in: J Neurol
July 2019

Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in the retina in both AD and AMD. While current diagnostic modalities for detecting Aβ in the brain are costly or invasive, Aβ in the retina can be noninvasively and conveniently imaged using modern photonic imaging systems such as optical coherence tomography (OCT). Moreover, since many of these retinal changes occur before degenerative changes can be detected in the brain, ocular amyloid biomarkers could be utilized to detect AD as well as AMD in their earliest stages when therapy may be most effective in halting disease progression. Novel technologies to quantify retinal biomarkers have the potential to facilitate early diagnosis and noninvasive monitoring of disease progression with important therapeutic implications.

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Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

July 2019

Volume

266

Issue

7

Start / End Page

1566 / 1577

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Retina
  • Neurology & Neurosurgery
  • Macular Degeneration
  • Humans
  • Brain
  • Amyloid beta-Peptides
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Ong, S. S., Proia, A. D., Whitson, H. E., Farsiu, S., Doraiswamy, P. M., & Lad, E. M. (2019). Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy. J Neurol, 266(7), 1566–1577. https://doi.org/10.1007/s00415-018-9028-z
Ong, Sally S., Alan D. Proia, Heather E. Whitson, Sina Farsiu, P Murali Doraiswamy, and Eleonora M. Lad. “Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.J Neurol 266, no. 7 (July 2019): 1566–77. https://doi.org/10.1007/s00415-018-9028-z.
Ong SS, Proia AD, Whitson HE, Farsiu S, Doraiswamy PM, Lad EM. Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy. J Neurol. 2019 Jul;266(7):1566–77.
Ong, Sally S., et al. “Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.J Neurol, vol. 266, no. 7, July 2019, pp. 1566–77. Pubmed, doi:10.1007/s00415-018-9028-z.
Ong SS, Proia AD, Whitson HE, Farsiu S, Doraiswamy PM, Lad EM. Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy. J Neurol. 2019 Jul;266(7):1566–1577.
Journal cover image

Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

July 2019

Volume

266

Issue

7

Start / End Page

1566 / 1577

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Retina
  • Neurology & Neurosurgery
  • Macular Degeneration
  • Humans
  • Brain
  • Amyloid beta-Peptides
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences